Features of the course of non-alcoholic liver steatosis in women of reproductive age and in menopause

Introduction. Non-alcoholic fatty liver disease (NAFLD) increases with age. The main risk factor for NAFLD and the progression of fibrosis is obesity. However, also occurs in 7% people normal body weight, mainly young women levels enzymes, whom can nevertheless progress. Aim. To assess features clinical laboratory manifestations non-alcoholic hepatic steatosis (NASP) reproductive age menopause, depending on degree Materials methods. We examined 86 NAS obesity, which 49 were (37.3 ± 1.7 years) 37 patients menopause (51.3 1.0 years). Determined: transaminases, total bilirubin, glucose, lipid spectrum, insulin, leptin, interleukin-6 (IL-6), vasculoendothelial growth (VEGF); mass index (BMI), atherogenicity (AI), HOMA-IR calculated. Liver was determined by ultrasound, excluded fibroelastography. Results. clinic both groups poor; there no signs fibrosis. In concomitant obesity dyslipidemia, hyperleptinemia, increased IL-6 endothelial damage form VEGF hyperproduction are recorded. At same time, dyslipidemia hyperleptinemia significant at age, more pronounced. Conclusion. NASP, most studied parameters marked transition to stage 1 leptin made it possible differentiate almost all degrees production significantly stages 2–3